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Long-Term Suppressive cART Is Not Sufficient to Restore Intestinal Permeability and Gut Microbiota Compositional Changes

Ancona, G., Merlini, E., Tincati, C., Barassi, A., Calcagno, A., Augello, M., Bono, V., Bai, F., Cannizzo, E. S., d’Arminio Monforte, A., & Marchetti, G. (2021). Long-Term Suppressive cART Is Not Sufficient to Restore Intestinal Permeability and Gut Microbiota Compositional Changes. Frontiers in immunology, 12, 639291.

The study explores the long-term effects of cART on markers of gut damage, microbial translocation, and paired gut/blood microbiota composition, with a focus on the role exerted by different drug classes. The results conclude that 24 months of cART only affects the gastrointestinal tract minorly.


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