Oral Microbiome in HIV-Infected Women: Shifts in the Abundance of Pathogenic and Beneficial Bacteria Are Associated with Aging, HIV Load, CD4 Count, and Antiretroviral Therapy

Lewy, T., Hong, B. Y., Weiser, B., Burger, H., Tremain, A., Weinstock, G., Anastos, K., & George, M. D. (2019). Oral Microbiome in HIV-Infected Women: Shifts in the Abundance of Pathogenic and Beneficial Bacteria Are Associated with Aging, HIV Load, CD4 Count, and Antiretroviral Therapy. AIDS research and human retroviruses, 35(3), 276–286.

https://healthhiv.org/wp-content/uploads/2022/09/Lewy-T.pdf

• The study looked at 16S rDNA-based pyrosequencing to compare the salivary microbiome in three groups: (1) Chronically HIV-infected women >50 years of age (aging); (2) HIV-infected women <35 years of age (young adult); and (3) HIV-uninfected age-matched women. The results displayed new evidence that HIV infection is associated with a shift toward an increased pathogenic footprint of the salivary microbiome.