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Aging with HIV

Systemic inflammation and the increased risk of inflamm-aging and age-associated diseases in people living with HIV on long-term suppressive antiretroviral therapy

August 27, 2019

This study evaluates the levels of systemic inflammation to better understand the risk of age-associated diseases in PLHIV on long-term suppressive ART using a large number of biomarkers of inflammation and immune activation. This study found that there is still a large amount of inflammation in those who are on ART as in those who were untreated.

Oral Microbiome in HIV-Infected Women: Shifts in the Abundance of Pathogenic and Beneficial Bacteria Are Associated with Aging, HIV Load, CD4 Count, and Antiretroviral Therapy

March 12, 2019

The study looked at 16S rDNA-based pyrosequencing to compare the salivary microbiome in three groups: (1) Chronically HIV-infected women >50 years of age (aging); (2) HIV-infected women <35 years of age (young adult); and (3) HIV-uninfected age-matched women.

Geriatric-HIV medicine: the geriatrician’s role

December 10, 2018

With the ever-growing population of aging people, the importance of geriatricians with HIV experience is growing. Comprehensive Geriatric Assessment is an important tool that could be used for this specific population, but it is noted that the current model would need to be adjusted to work better with aging PLWH.

Patient and provider perceptions of a comprehensive care program for HIV-positive adults over 50 years of age: The formation of the Golden Compass HIV and aging care program in San Francisco

December 5, 2018

People living with HIV (PLWH) are living longer, developing comorbidities and aging-related syndromes. New care models are needed to address the combined burden and complexity of HIV and its comorbidities in this group. The goal of this study is to describe qualitative data from patients and providers that informed the development of a comprehensive care model for older PLWH.

Factors associated with social deprivation among older persons living with HIV

November 22, 2018

Social deprivation is a comorbidity that many older people living with HIV face. The study analyzed the relationship between people living with HIV and social deprivation. Social deprivation was not related to HIV status but showed that OPWH that suffered from social deprivation received little support from social workers.

A continuum of HIV care describing mortality and loss to follow-up: a longitudinal cohort study

June 4, 2018

A cross-sectional study assessed how effective it was for those on HIV meds to not transmit to others, along with how high the loss to follow-up was in various HIV programs. They found that there was a high loss of follow-up in HIV care programs, but it highlighted the need for intervention as well as an increase in rates of viral suppression.

HIV and aging: Role of the microbiome

January 12, 2018

The researchers in this study observe gut bacteria and the microbiome to see its impact on those aging with HIV.

Aging in HIV-Infected Subjects: A New Scenario and a New View

December 21, 2017

Researchers examine the age-related conditions in older persons with HIV and address clinical management according to the author’s expertise and published literature. The researchers aim to advance the debate about the most appropriate management of this population, including less well-studied aspects, such as the frequency of screening for psychological/mental and social and functional capabilities.

Clinical implications of aging with HIV infection: perspectives and the future medical care agenda

March 9, 2017

With increasing numbers of aging PLWH, HIV care programs need to begin involving geriatric medicine practices. Researchers suggest that an aging HIV+ person’s care should involve a multidisciplinary team that would include primary care physicians, social workers, and geriatricians.

Faces of Frailty in Aging with HIV Infection

February 16, 2017

The development of frailty is a risk factor for most aging adults however OPWH are at a greater risk of this development. Prevention efforts need to be made to help OPWH successfully age without disability or loss of independence. It also discusses how the needs for OPWH should be evaluated. 

Medical, Social and Supportive Services for Older Adults with HIV

November 29, 2016

A very broad look at essential community-based supportive services to promote healthy aging of OPWH. It also discusses the potential barriers to those who are older suffering from HIV. This article also mentions that it would be most beneficial for physicians to address the whole individual including the environment and community that they live in as well as their medical information.

Article: HIV and Aging

October 6, 2016

People who are living with HIV are living longer lives which may bring on new challenges in regards to the comorbidities that can occur in older people with HIV (OPWH). Early diagnoses of these comorbidities, geriatric care is essential to the continuation of life and quality of life for these patients.

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