Senotherapeutics for HIV and aging

Monocytes in HIV and SIV Infection and Aging: Implications for Inflamm-Aging and Accelerated Aging

With ART and the extended lifespan of PLWH, HIV comorbidities also include aging—most likely due to accelerated aging—as well as cardiovascular, neurocognitive disorders, lung and kidney disease, and malignancies. The broad evidence suggests that HIV with ART is associated with accentuated aging and that the age-related comorbidities occur earlier, due in part to chronic immune activation, co-infections, and possibly the effects of ART alone.

A continuum of HIV care describing mortality and loss to follow-up: a longitudinal cohort study

A cross-sectional study assessed how effective it was for those on HIV meds to not transmit to others, along with how high the loss to follow-up was in various HIV programs. They found that there was a high loss of follow-up in HIV care programs, but it highlighted the need for intervention as well as an increase in rates of viral suppression.